Chris O'Brien

Chris O'Brien may refer to:


 * Chris O'Brien (American football) (1881–1951), owner of the Chicago Cardinals and co-founder of the National Football League
 * Chris O'Brien (baseball) (born 1989), minor league baseball player
 * Chris O'Brien (rugby) (born 1950), Welsh rugby league player
 * Chris O'Brien (surgeon) (1952–2009), Australian oncologist and surgeon
 * Chris O'Brien (rugby union) (born 1964), United States rugby union player