City of Hope

City of Hope may refer to:
 * City of Hope (1991 film), a film taking place in fictitious Hudson City, New Jersey
 * City of Hope (1948 film), a French drama film
 * City of Hope National Medical Center, a cancer center in Duarte, California
 * City of Hope (charity), the medical center's charity
 * City of Hope, a song by Journey from Eclipse, 2011