Cleveland, Painesville and Ashtabula Railroad

Cleveland, Painesville and Ashtabula Railroad may refer to:
 * Cleveland, Painesville and Ashtabula Railroad (1848–1869), predecessor of the Lake Shore and Michigan Southern Railway (New York Central system)
 * Cleveland, Painesville and Ashtabula Railroad (1879–1886), predecessor of the New York, Chicago and St. Louis Railroad (Nickel Plate)