Cobyrinate a,c-diamide synthase

Cobyrinate a,c-diamide synthase, cobyrinic acid a,c-diamide synthetase, CbiA (gene)) is an enzyme which catalyses the chemical reaction


 * 2 ATP + cobyrinate + 2 L-glutamine + 2 H2O $$\rightleftharpoons$$ 2 ADP + 2 phosphate + cobyrinate a,c-diamide + 2 L-glutamate (overall reaction)
 * (1a) ATP + cobyrinate + L-glutamine + H2O $$\rightleftharpoons$$ ADP + phosphate + cobyrinate c-monamide + L-glutamate
 * (1b) ATP + cobyrinate c-monamide + L-glutamine + H2O $$\rightleftharpoons$$ ADP + phosphate + cobyrinate a,c-diamide + L-glutamate

This enzyme is a glutamine amidotransferase, part of the biosynthetic pathway to cobalamin (vitamin B12) in anaerobic bacteria such as Salmonella typhimurium and Bacillus megaterium.