CofC

CofC may refer to:


 * Church of Christ, non-denominational Christian church influenced by the Restoration Movement
 * Community of Christ, American-based international church, focused on peace and justice
 * College of Charleston, public university located in Charleston, South Carolina
 * Certificate of Conformity, Conformance or Compliance Certificate of Conformity
 * 2-phospho-L-lactate guanylyltransferase, an enzyme

CoFC may refer to:
 * United States Court of Federal Claims

COFC may refer to:
 * "Container on Flatcar", a form of intermodal freight transport with intermodal containers
 * Certificate of Formula Compliance Certificate of Formula Compliance
 * Cherry Orchard F.C., an Irish football club
 * Cookstown Olympic F.C., a Northern Irish football club