Cole Creek (Prairie Fork tributary)

Cole Creek is a stream in Callaway and Montgomery counties in the U.S. state of Missouri. It is a tributary of Prairie Fork of the Loutre River.

The stream headwaters arise in eastern Callaway County at 38.79306°N, -91.67167°W and flows northeast to its confluence with Prairie Fork in western Montgomery County at 38.84639°N, -91.60833°W.

Cole Creek has the name of a pioneer citizen.