Cube: 3D Puzzle Mayhem

Cube: 3D Puzzle Mayhem, known as simply Cube in North America and as Simple 2500 Series Portable!! Vol. 10: The IQ Cube: Moyatto Atama o Puzzle de Sukkiri! (SIMPLE 2500 シリーズ ポータブル!! Vol.10 THE IQ CUBE 〜モヤっと頭をパズルでスッキリ！〜) (part of the Simple 2500 Portable series), is a puzzle video game developed by Metia Interactive and published by D3 Publisher in 2007.

Reception
The game received "mixed" reviews according to the review aggregation website Metacritic. In Japan, Famitsu gave it a score of 25 out of 40.