Cyclopentadecanolide

Cyclopentadecanolide is a natural macrolide lactone and a synthetic musk.

Natural occurrence
Cyclopentadecanolide occurs in small quantities in angelica root essential oil and is responsible for its musklike odor.

Production
Cyclopentadecanolide is produced synthetically by ring expansion of cyclotetradecanone. Another synthesis route is the depolymerization of polyesters of 15-hydroxypentadecanoic acid.

Uses
Cyclopentadecanolide is used as a musklike perfume fixative in fine fragrances and as a flavoring agent. It is a substitute for the extremely expensive animal musk.