D49

D49 may refer to:
 * Columbus Municipal Airport (North Dakota)
 * D49 motorway (Czech Republic)
 * D49 road (Croatia)
 * Falcon School District 49, in Colorado
 * Kyrie in D minor, D 49 (Schubert)
 * LNER Class D49, a 1927 British class of 4-4-0 steam locomotives
 * Semi-Slav Defense, a chess opening