DES

DES or Des may refer to:

Computing

 * Data Encryption Standard, a block cipher that is no longer secure for today's standards
 * DirectShow Editing Services, an Application Programming Interface
 * Discrete event simulation, a kind of scientific modelling

Education

 * Deccan Education Society, a private education institution based in Pune, India.
 * Department of Education and Science (UK), the former name of the Department for Education and Skills
 * Diplôme d'études supérieures, a former degree used in France and French-speaking countries

Medical

 * Diethylstilbestrol, a synthetic estrogen and the origin of the phrase "DES daughter"
 * DES gene, which encodes the desmin protein
 * Diffuse esophageal spasm, a disorder of the esophagus
 * Dissociative Experiences Scale, a questionnaire to screen for dissociative identity disorder
 * Drug-eluting stent, a medical device
 * Dry eye syndrome, also known as keratoconjunctivitis sicca
 * Dysequilibrium syndrome, a congenital disorder of the nervous system

Other uses

 * Dar es Salaam
 * Dark Energy Survey, an astronomy project
 * Deep Ecliptic Survey, an astronomy project
 * Deep eutectic solvent, an ionic solvent
 * Defence Equipment and Support, British MOD's defence procurement arm
 * Delivered Ex Ship, an international sales term
 * Detached eddy simulation, a model in fluid dynamics
 * Des, a three-part British series about serial killer Dennis Nilsen
 * Desroches Airport, by IATA code
 * Arizona Department of Economic Security, a US government organization providing a variety of social support services to Arizona residents
 * Desmond (name), a male given name in shortened form
 * Desiree (given name), a female given name in shortened form
 * Diethyl sulfate, an organic chemical