DXS

DXS may refer to:


 * Department of External Services, a fictional U.S. intelligence agency on the TV show MacGyver
 * Dexus, Australian stock exchange ticker symbol
 * DXS, a web service component formerly known as Get Hot New Stuff in KDE Software Compilation 4
 * Deep Extragalactic Survey, one of five components of the UKIRT Infrared Deep Sky Survey
 * Diffuse X-ray Spectrometer, instrumentation on the NASA Space Shuttle mission STS-54