De Francesco

De Francesco (or de Francesco) is an Italian surname. Notable people with this surname include:


 * Alberto De Francesco (born 1994), Italian football player
 * Devlin DeFrancesco (born 2000), Canadian-Italian auto racing driver
 * Francesco De Francesco (born 1977), Italian football striker
 * Grete De Francesco (1893–1945), German-speaking writer
 * Joey DeFrancesco (1971–2022), American jazz organist, trumpeter, saxophonist, and occasional singer
 * John DeFrancesco (born 1940), American jazz organist and vocalist
 * Johnny DeFrancesco (born 1965), merican blues guitarist
 * Sebastian de Francesco (born 1981), Italian football striker
 * Matteuccia de Francesco (died 1428), an alleged Italian witch and nun
 * Tony DeFrancesco (born 1963), American baseball coach