De Santi

de Santi or Desanti is a surname. Notable people with the surname include:


 * Antonio Álvarez Desanti (born 1958), Costa Rican politician
 * Dominique Desanti (1920–2011), French writer
 * Guido De Santi (1923–1998), Italian cyclist
 * Marco de Santi (born 1983), Brazilian vert skater
 * Jean-Toussaint Desanti (1914–2002), French educator and philosopher