De Soto, Nebraska

De Soto is an unincorporated community in Washington County, Nebraska, United States. It was named in honor of the sixteenth-century Spanish explorer, Hernando De Soto. De Soto was founded in 1855 and served as the county seat from 1858-1866. During its heyday, the town hosted many flourishing new businesses: hotels, saloons, stores, newspapers and banks.

De Soto contains farmland with about three families residing there.