De Vargas

De Vargas is a Spanish surname. Notable people with the surname include:


 * Andrés de Vargas (1613–1647), Spanish painter
 * Diego de Vargas (1643–1704), Spanish colonial governor
 * Francisco de Vargas (born 1970), Paraguayan lawyer and politician
 * Francisco de Vargas y Mexia (died 1566), Spanish diplomat and writer
 * Gutierre de Vargas Carvajal (1506–1559), Spanish Roman Catholic bishop
 * José de Vargas Ponce (1760–1821), Spanish erudite, poet and writer
 * Luis de Vargas (1502–1568), Spanish Renaissance painter
 * Urbán de Vargas (1606–1656), Spanish Baroque composer
 * Valentin de Vargas (1935–2013), American actor