De Villegas

De Villegas is a surname. Notable people with the surname include:


 * Andrés Rodríguez de Villegas (died 1633), Spanish colonial governor
 * Diogo Ortiz de Villegas (1457–1519), Spanish Roman Catholic priest
 * Esteban Manuel de Villegas (1589–1669), Spanish poet
 * Hipólito de Villegas (c. 1761 – 1838), Chilean politician
 * Pedro Ruiz de Villegas II (c. 1304–1355), Spanish noble
 * Pedro de Villegas Marmolejo (1519–1596), Spanish Renaissance sculptor and painter
 * Maria de Villegas de Saint-Pierre (1870-1941), Belgian Countess, writer, nurse and philanthropist