De la Serna

de la Serna is a surname. Notable people with the name include:


 * Jacobo de la Serna (born 1965), American ceramic artist, Spanish Colonial scholar, and painter
 * Jorge Juan Crespo de la Serna (1887–1978), Mexican artist, art critic and art historian
 * José de la Serna e Hinojosa (1770–1832), Spanish general and Viceroy of Peru
 * Juan Pérez de la Serna (1570–1631), seventh Archbishop of Mexico
 * Pedro Gómez de la Serna (1806–1871), Spanish jurist and politician
 * Ramón Gómez de la Serna (1888–1963), Spanish writer
 * Rodrigo de la Serna (born 1976), Argentine actor