Defoe

Defoe may refer to:

People

 * Defoe (surname), most notably English author Daniel Defoe

Places

 * Defoe, Webster County, West Virginia, an unincorporated community

Other uses

 * Defoe (comics), a zombie story
 * Defoe Shipbuilding Company, a former shipyard in Bay City, Michigan
 * Operation Defoe, a Second World War reconnaissance by the British Special Air Service
 * Defoe (horse) (2014–2020), Thoroughbred racehorse