Donough O'Brien

Donough O'Brien may refer to:
 * Donough O'Brien (author) (born 1939), marketing, public relations executive and author
 * Donough O'Brien (cricketer) (1879–1953), Welsh-born Irish cricketer
 * Sir Donough O'Brien, 1st Baronet (1642–1717), Irish politician and baronet
 * Donough O'Brien, 16th Baron Inchiquin (1897–1968)
 * Donough O'Brien, 2nd Earl of Thomond (died 1553)
 * Donogh O'Brien, 4th Earl of Thomond (died 1624)
 * Donough O'Brien (died 1582)