Dr. Samuel Guthrie House

Dr. Samuel Guthrie House is a historic home located at Hounsfield in Jefferson County, New York. The home comprises a rectangular two-story, five-by-two-bay, brick Federal style core building and a rectangular one-story rear wing. The rear wing is in three sections: a section constructed around 1822, an addition from the early 20th century, and a third from about 1910.

It was listed on the National Register of Historic Places in 1989.