Draft:Atlas of Variant Effects Alliance

The Atlas of Variant Effects Alliance (AVE), founded in 2020, is an international collaborative aiming to catalog the impact of all possible genetic variants for disease-related functional elements. The goal of the Alliance is to create a comprehensive atlas, a collection of variant effect maps, for important regions of human and human pathogen genomes that could ultimately assist in the diagnosis, prognosis, and treatment of disease. Variant effect maps are built using multiplexed assays of variant effect (MAVEs), a family of methods that involve mutagenesis of a DNA-encoded protein or regulatory element followed by a multiplexed assay for some aspect of function. The findings, materials, and resources generated by the Alliance are freely available to the research community.

Organization
AVE was founded and is operated at the Department of Genome Sciences at University of Washington, Seattle, USA and the Brotman Baty Institute. The AVE alliance is composed of researchers, technologists, analysts, clinicians, patients and funders from over 100 institutions and 39 countries. AVE is funded in part through the Brotman Baty Institute and the National Human Genome Research Institute, via funding from the Center of Excellence in Genome Science grant (NHGRI RM1HG010461).

Activities
AVE organizes an international annual meeting, the Mutational Scanning Symposium. AVE also hosts a monthly seminar series.

AVE work streams

 * Clinical Variant Interpretation
 * Data Coordination and Dissemination
 * Experimental Technology and Standards
 * Analysis, Modeling, and Prediction