Draft:CoRSIVs

CoRSIVs, or Correlated Regions of Systemic Interindividual Variation, are genomic regions identified for their consistent DNA methylation levels across various tissues. These regions exhibit significant interindividual methylation variation, making them a focal point in epigenetic studies, particularly in understanding diseases like schizophrenia. By analyzing DNA methylation at CoRSIVs, researchers aim to bridge the gap between epigenetic predisposition and manifestation of diseases, offering insights into the complex interplay of genetic and environmental factors in disease etiology.

The identification of CoRSIVs through comprehensive genomic analysis highlights their potential as biomarkers for understanding disease mechanisms. By focusing on these regions, researchers can infer epigenetic regulation patterns across the body, including the brain, from peripheral tissues such as blood. This approach is instrumental in circumventing the challenges posed by the cell type-specificity of DNA methylation and the potential for reverse causality in epigenetic epidemiology.