Draft:Enzyme-linked single molecule array (eSimoa)

eSimoa (enzyme-linked single molecule array) is an advanced diagnostic tool that significantly enhances the sensitivity and resolution of biomolecular detection. This technology is pivotal in fields like clinical diagnostics, drug discovery, and basic biological research due to its ability to detect biomolecules at concentrations previously unachievable with traditional assays.

Technology
The eSimoa platform utilizes paramagnetic beads to attach biomolecules or enzymes, facilitating the measurement of enzymatic reactions at the single-molecule level. This method improves the detection limits for various enzymes and biomolecules, allowing for the precise quantification of low-abundance proteins and the activity of enzymes such as protein kinases and telomerases.

Applications
eSimoa's high sensitivity is particularly beneficial for tracking enzymatic activities and their inhibition, which is crucial for developing new pharmaceuticals and understanding disease mechanisms. Its applications extend to evaluating enzyme inhibitors, providing insights into their effectiveness and potential as therapeutic agents.

Origins
Chi-An Cheng at National Taiwan University (NTU) has claimed that her team developed this innovative technology. However, this claim is contested by the existence of prior publications by David R. Walt's team at Harvard University, who published their work on eSimoa in 2020. This earlier documentation by Walt's team suggests a prior contribution to the development of the technology.