E50

E50 or E-50 may refer to:
 * Nimzo-Indian Defence, Encyclopaedia of Chess Openings code
 * E-50 Standardpanzer, a German World War II tank model in the Entwicklung series
 * European route E50, a road connecting Brest in France with Makhachkala in the Russian Republic of Dagestan
 * M113 E50, a version of the Mercedes-Benz M113 engine
 * M2 E-50, a version of the M2 Browning machine gun
 * Nokia E50, a smartphone
 * HMS E50, a British E class submarine of the First World War
 * E50, a road route in Japan:
 * Kita-Kantō Expressway
 * Higashi-Mito Road
 * Hitachinaka Road