EPS15

Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the EPS15 gene.

Function
This gene encodes a protein that is part of the EGFR pathway. The protein is present at clathrin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Interactions
EPS15 has been shown to interact with:
 * CRK
 * EPN1,
 * HGS,
 * HRB, and
 * REPS2.