Edward Ayscough

Edward Ayscough may refer to:
 * Edward Ayscu (1550–?), or Ayscough (1550–1616), English historian
 * Edward Ayscough (of Nuthall) (c. 1590–after 1641), MP for Stamford 1624
 * Sir Edward Ayscough (born 1596) (1596–by 1654), English MP for Lincoln and Lincolnshire
 * Sir Edward Ayscough (died 1668) (c. 1618–1668), English MP for Great Grimsby 1659
 * Sir Edward Ayscough (died 1699) (1650–1699), English MP for Great Grimsby 1685–1699