Ent-kaurene oxidase

Ent-kaurene oxidase (, Formerly ) is an enzyme with systematic name ent-kaur-16-ene,NADPH:oxygen oxidoreductase (hydroxylating). This enzyme catalyses the following chemical reaction


 * ent-kaur-16-ene + 3 NADPH + 3 H+ + 3 O2 $$\rightleftharpoons$$ ent-kaur-16-en-19-oate + 3 NADP+ + 4 H2O (overall reaction)
 * (1a) ent-kaur-16-ene + NADPH + H+ + O2 $$\rightleftharpoons$$ ent-kaur-16-en-19-ol + NADP+ + H2O
 * (1b) ent-kaur-16-en-19-ol + NADPH + H+ + O2 $$\rightleftharpoons$$ ent-kaur-16-en-19-al + NADP+ + 2 H2O
 * (1c) ent-kaur-16-en-19-al + NADPH + O2 $$\rightleftharpoons$$ ent-kaur-16-en-19-oate + NADP+ + H2O

Ent-kaurene oxidase requires cytochrome P450 and is inhibited by paclobutrazol.