Epi-isozizaene 5-monooxygenase

Epi-isozizaene 5-monooxygenase (, CYP170A1) is an enzyme with systematic name (+)-epi-isozizaene,NADPH:oxygen oxidoreductase (5-hydroxylating). This enzyme catalyses the following chemical reaction


 * (+)-epi-isozizaene + 2 NADPH + 2 H+ + 2 O2 $$\rightleftharpoons$$ albaflavenone + 2 NADP+ + 3 H2O (overall reaction)
 * (1a) (+)-epi-isozizaene + NADPH + H+ + O2 $$\rightleftharpoons$$ (5S)-albaflavenol + NADP+ + H2O
 * (1b) (5S)-albaflavenol + NADPH + H+ + O2 $$\rightleftharpoons$$ albaflavenone + NADP+ + 2 H2O
 * (2a) (+)-epi-isozizaene + NADPH + H+ + O2 $$\rightleftharpoons$$ (5R)-albaflavenol + NADP+ + H2O
 * (2b) (5R)-albaflavenol + NADPH + H+ + O2 $$\rightleftharpoons$$ albaflavenone + NADP+ + 2 H2O

This cytochrome P450 enzyme is purified from bacterium Streptomyces coelicolor.