Erythromycin 12 hydroxylase

Erythromycin 12 hydroxylase (, EryK) is an enzyme with systematic name erythromycin-D,NADPH:oxygen oxidoreductase (12-hydroxylating) . This enzyme catalyses the following chemical reaction


 * erythromycin D + NADPH + H+ + O2 $$\rightleftharpoons$$ erythromycin C + NADP+ + H2O

Erythromycin 12 hydroxylase is responsible for the C-12 hydroxylation of the macrolactone ring.