Esca

Esca can refer to:


 * The esca or illicium, a modified luminescent fin ray found in anglerfish
 * Esca (grape disease)
 * the Ezka, a river in the Basque country known as "Esca" in Spanish
 * ESCA or Electron Spectroscopy for Chemical Analysis, now known as X-ray photoelectron spectroscopy (XPS)