F53

F53 may refer to:
 * F53 (classification), a disability sport classification
 * English Electric Lightning F.53, a British fighter aircraft
 * Franklin County Airport (Texas)
 * HMS Ausonia (F53), a Cunard ocean liner requisitioned for the Royal Navy
 * HMS Janus (F53), a J-class destroyer of the Royal Navy
 * HMS Undaunted (F53), a U-class destroyer of the Royal Navy