Fall 2021 Chattanooga FC season

The Fall 2021 Chattanooga FC season was the club's third professional season playing in the National Independent Soccer Association and 14th overall since being established in 2009.

NISA Independent Cup
Details for the 2021 NISA Independent Cup were released on June 10. Chattanooga were placed in the Southeast Region for the second straight year along with three United Premier Soccer League teams; Savannah Clovers FC, Soda City FC (both of which took part in the 2020 edition), and 2020 Fall UPSL Champion Atletico Atlanta.

Chattanooga won the regional title for a second straight season after two matches following a win at Savanah and a tie between Soda City and Atlanta.

National Independent Soccer Association season
Details regarding the Fall season were released on June 16.

Appearances and goals
! colspan="14" style="background:#dcdcdc; text-align:center"| Goalkeepers

! colspan="18" style="background:#dcdcdc; text-align:center"| Defenders

! colspan="18" style="background:#dcdcdc; text-align:center"| Midfielders

! colspan="18" style="background:#dcdcdc; text-align:center"| Forwards


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