Fast endophilin-mediated endocytosis

Fast endophilin-mediated endocytosis (FEME) is an endocytic pathway found in eukaryotic cells. It requires the activity of endophilins as well as dynamins, but does not require clathrin.

In Clathrin-dependent endocytic pathways, endosomes budding from the cell membrane into the cell will form in clathrin pits, and be coated by clathrin triskelions. In FEME however, endosomes form when coated by actin, and internalise endophilin A2.

Function
Each endocytic pathway focuses on a particular component, and FEME is primarily involved in transporting receptors. These include receptors for acetylcholine and IL-2.

Associated proteins

 * EGFR
 * HGFR
 * VEGFR
 * PDGFR
 * NGFR
 * IGF1R
 * SHIP1
 * SHIP2