Ferredoxin—NAD(+) reductase

In enzymology, a ferredoxin–NAD+ reductase is an enzyme that catalyzes the chemical reaction:


 * reduced ferredoxin + NAD+ $$\rightleftharpoons$$ oxidized ferredoxin + NADH + H+

Thus, the two substrates of this enzyme are reduced ferredoxin and NAD+, whereas its 3 products are oxidized ferredoxin, NADH, and H+. This enzyme participates in fatty acid metabolism.

This enzyme belongs to the family of oxidoreductases, specifically those acting on iron-sulfur proteins as donor with NAD+ or NADP+ as acceptor.

The systematic name of this enzyme is ferredoxin:NAD+ oxidoreductase. There are a variety of names in common use:
 * ferredoxin–nicotinamide adenine dinucleotide reductase
 * ferredoxin reductase
 * NAD+-ferredoxin reductase
 * ferredoxin–NAD+ reductase
 * ferredoxin–linked NAD+ reductase
 * ferredoxin–NAD reductase

When NAD molecule is in its reduced form, the enzyme is referred to as:
 * NADH-ferredoxin oxidoreductase
 * reduced nicotinamide adenine dinucleotide-ferredoxin
 * NADH-ferredoxin reductase
 * NADH flavodoxin oxidoreductase
 * NADH2-ferredoxin oxidoreductase

Other enzymes in the family include:
 * NADH-ferredoxin NAP reductase (component of naphthalene dioxygenase multicomponent enzyme system)
 * NADH-ferredoxin TOL reductase (component of toluene dioxygenase)

Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code.