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Summary
An overview of an immune response during allogeneic stem cell transplantation: A SNP in the coding region of the recipient is polymorphic from the amino acid sequence of a donor's T cell. The T cell receptor specific for peptide and MHC molecule recognizes the self-peptide bound to the groove of HLA matched gene as forgein and initiates an immune response. The donor's CD8+ cell targets the recipient’s nucleated cell resulting in graft-versus-host disease.