File talk:Bergamottin biosynthesis.svg

The final product ("8, bergamottin") is shown as being derived from bergapten (7). But it seems to be that it would make much more sense if it were derived from bergaptol (6). If 7 were to be converted to 8 it would first have to undergo demethylation back to 6 anyway - the methylation/demethylation sequence is entirely superfluous. ChemNerd (talk) 17:36, 10 November 2015 (UTC)
 * At frist glance the additional methylation steps looks like entirely superflous indeed. According to J. Am. Soc. Hortic. Sci. (2011) 136, 358–363 or Int. J. Mol. Sci. (2018) 19, 4048 and as well J. Food Drug. Anal. (2017) 25, 71–83, the additional methylation step seems to be a key step for the enzymatic catalyzed formation reaction of bergamottin. Hence this reaction step can't get bypassed for the enzyme reaction. In organic laboratories it might be possible to realise the direct geranylation step, e.g. with other non-enymatic catalyst systems. The dispute was discussed at de:Wikipedia:Redaktion_Chemie/Qualitätssicherung as well. Chem Sim 2001 (talk) 07:39, 27 July 2021 (UTC)