File talk:Signal transduction v1.png

At least one section of this diagram seems to be badly flawed: the canonical Raf pathway involves phosphorylation and activation of an MEKK kinase (aka STE11 or MAP3K), which in turns activates a MEK kinase (aka MKK, or STE7), which then in turn activates a MAPK, such as ERK, JNK or p38. So, the MEK just downstream of Raf should probably be a MEKK, and different classes of MKK should be upstream from the ERK and JNK MAPKs, with the MAPK entry redundant, and the MEK and MKK entries also mutually redundant.

It's quite possible that any of the reactions shown do exist somewhere in biology, but not be part of the canonical pathway.

There is also a possible problem with the "abnormality sensor" pathway, which appears to be mediated by caspase-9 in the original (hand-drawn?) image, but not in this version. The original image is here: http://en.wikipedia.org/wiki/File:Signal_transduction_pathways.jpg —Preceding unsigned comment added by 63.201.146.130 (talk) 16:18, 8 September 2009 (UTC)

I kappa B
Also shouldn't IkB be shown inhibiting NF-kB rather than activating it? Repapetilto (talk) 10:17, 8 October 2009 (UTC)

Chart is clearly Outdated
Missing the Vascular Endothelial Growth Factor A VEGFA pathway is missing - the medicine called NOV-002 follows that important pathway. That chart is 6 years old.

Alex Kalman —Preceding unsigned comment added by 4.238.245.213 (talk) 22:03, 20 December 2009 (UTC)

TNF is misplaced
TNF-alpha doesn't bind to Fas Receptor, but rather to its own cytokine receptor (in fact TNF is the paradigmatic example capable to activate apoptosis by a different pathway other than the intrinsic [Cytochrome C] or the extrinsic [FasL] pathway). I also agree with Repapetilto that IkB acts as an NF-kB inhibitor instead of an activator, thus its name. 80.174.254.211 (talk) 08:07, 30 December 2010 (UTC)

Rb and E2F
Rb inhibits E2F. 86.49.83.33 (talk) 05:52, 18 April 2011 (UTC)

Names on the right
Names on the right side appear to be vandalized or nonsense. — Preceding unsigned comment added by 108.243.106.82 (talk • contribs)
 * Do you mean frizzled, dishevelled, patched, and hedgehog? As silly as they sound, they are all real names of proteins.  Deli nk (talk) 18:42, 14 April 2016 (UTC)