First Interstate

First Interstate could refer to:
 * First Interstate Bancorp, a former bank now a part of Wells Fargo
 * First Interstate BancSystem, the current bank based in the upper American Mountain West
 * Interstate 1, numerically the first interstate highway
 * Pennsylvania Turnpike, one of three highways claimed to be the first interstate highway
 * Missouri interstates 44 and 70, second of three states claiming first interstate highways
 * Interstate 44 in Missouri
 * Interstate 70 in Missouri
 * Interstate 70 in Kansas, claimed first paved in interstate highway system