First Kill

First Kill may refer to:
 * First Kill (2017 film), an American film
 * First Kill (compilation), a 1986 compilation album by Tygers Of Pan Tang
 * First Kill (2001 film), a Dutch documentary film
 * "First Kill", a song by Amon Amarth on the 2016 album Jomsviking
 * "Chuck Versus the First Kill", a 2009 episode of Chuck
 * First Kill (TV series), a 2022 supernatural teen drama television series