Flight 253

Flight 253 may refer to:


 * Linea Aeropostal Venezolana Flight 253 (June 1956), an airliner that crashed in the Atlantic Ocean off New Jersey on 20 June 1956
 * Linea Aeropostal Venezolana Flight 253 (November 1956), an airliner that crashed in Venezuela on 27 November 1956
 * Seaboard World Airlines Flight 253A, Soviet-American airspace incident of 1 July 1968
 * El Al Flight 253, attacked by terrorists while departing from a layover in Athens, Greece on 26 December 1968
 * Northwest Airlines Flight 253, attempted terrorist bombing incident of 25 December 2009