Formimidoyltransferase cyclodeaminase

Formimidoyltransferase cyclodeaminase or formiminotransferase cyclodeaminase (gene symbol FTCD in humans) is a bifunctional enzyme that catalyzes the following reactions:


 * conversion of formiminoglutamate and tetrahydrofolate into formiminotetrahydrofolate and glutamate (glutamate formimidoyltransferase activity, )
 * subsequent deamination of formiminotetrahydrofolate to 5,10-methenyltetrahydrofolate and ammonia (formimidoyltetrahydrofolate cyclodeaminase activity, )

Its name comes from the two activities it catalyzes.

Role in pathology
Mutations of the FTCD gene cause glutamate formiminotransferase deficiency.