Francis Sykes

Francis Sykes may refer to:


 * Sir Francis Sykes, 1st Baronet (1732–1804), British diplomat, MP
 * Sir Francis Sykes, 2nd Baronet (c.1767–1804), MP for Wallingford
 * Sir Francis Sykes, 3rd Baronet (c.1799–1842), husband of Lady Henrietta Sykes, lover of Benjamin Disraeli