Francisco Castillo

Francisco Castillo may refer to:


 * Francisco Castillo Fajardo, Marquis of Villadarias (1642–1716), Spanish general
 * Francisco Castillo Nájera (1886–1954), Mexican diplomat
 * Francisco Castillo (footballer) (born 1985), Chilean footballer
 * Francisco Castillo (water polo) (1921–1997), Spanish water polo player