Francisco Santos

Francisco Santos may refer to:
 * Francisco Dos Santos (born 1974), Brazilian footballer
 * Francisco Santos (swimmer, born 1962), Angolan/Portuguese swimmer, artist and writer, also known as Xesko
 * Francisco Santos (swimmer, born 1998), Portuguese_swimmer
 * Francisco Santos (baseball) (born 1974), former Major League Baseball outfielder
 * Francisco Santos (footballer) (born 1904), Portuguese footballer
 * Francisco Santos Calderón (born 1961), Colombian politician and journalist
 * Francisco Santos Leal (born 1968), Spanish mathematician
 * Francisco Cabrera Santos (1946–2010), mayor of Valencia, Carabobo, Venezuela
 * Francisco Santos, Piauí, a municipality in the state of Piauí, Brazil