Frank Byrne

Frank or Frankie Byrne may refer to:


 * Frank M. Byrne (1858–1927), American politician
 * Frank Byrne (Irish nationalist) (1848–1894), an instigator of the Irish National Invincibles
 * Frank Byrne (Australian politician) (c. 1836–1923), NSW politician
 * Frank Byrne (rugby union), (born 1938), Irish rugby union player
 * Frankie Byrne (Gaelic footballer) (1924–2019), played for Meath GAA
 * Frankie Byrne (EastEnders), fictional character
 * Frankie Byrne (broadcaster) (1922–1993), public relations consultant and broadcaster