Frank Guthrie

Frank Guthrie may refer to:


 * Frank Guthrie (politician) (1893–1955), Australian politician
 * Frank Guthrie (rugby union) (1869–1954), South African rugby player
 * Frank Edwin Guthrie (1923-1994), entomologist, recipient of the 1983 North Carolina Award for Science
 * Frank Guthrie (swimming coach), member of the International Swimming Hall of Fame