Frizzled-6

Frizzled-6 (Fz-6) is a protein that in humans is encoded by the FZD6 gene.

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for WNT signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other FZD family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif. Fz-6 is believed to be the receptor for the WNT4 ligand.

Interactions
Fz-6 has been shown to interact with secreted frizzled-related protein 1.