GCSE (disambiguation)

GCSE is the initialism of General Certificate of Secondary Education.

GCSE can also refer to:
 * Global common subexpression elimination, an optimization technique used by some compilers.
 * "Ghetto Children Sex Education", a single released by UK hip-hop artist Blak Twang.
 * Grand Cross of the Saxe-Ernestine House Order, a historical German Ducal award.
 * Grand Cross of the Military Order of Saint James of the Sword, a Portuguese order of chilvary.