GCSS

GCSS may refer to:
 * Game Critter Super-Squad!, a comic strip
 * GEWEX Cloud System Study, a meteorological study by the Global Energy and Water Exchanges
 * Global Combat Support System and GCSS-Army, a framework for managing military logistics
 * Government Comprehensive Secondary School, Port Harcourt, Rivers State, Nigeria
 * Grand Cross of the Order of St. Sylvester, a class in one of the orders of knighthood of the Holy See
 * Gwinnett College - Sandy Springs, Lilburn, Georgia, United States