GME

GME may refer to:

Companies

 * GameStop (stock ticker symbol GME), an American video game retailer
 * General Microelectronics, a defunct American semiconductor manufacturer
 * General Motors Egypt
 * General Motors Europe
 * Green Mountain Energy, American company
 * Guardian Media Entertainment, collaboration between the National Hockey League and comics creator Stan Lee

Education

 * Gaelic medium education in Scotland
 * Graduate medical education

Other

 * East Germanic languages
 * GME of Deutscher Wetterdienst, weather prediction model of the German Weather Service
 * Generic Modeling Environment, software modelling tool
 * Granulomatous meningoencephalitis, disease of the central nervous system of dogs and, rarely, cats
 * Greater Middle East, a region